Dados do Trabalho

Título

A CASE-CONTROL STUDY TO EVALUATE THE RISK FACTORS OF PEYRONIE´S DISEASE

Introdução e Objetivo

Background: Peyronie's disease (PD) is a benign pathology that develops fibrous plaques within the tunica albuginea of the penis, causing penile tortuosity, shortening in length, painful erections and erectile dysfunction. Although the disease was described more than 250 years ago, the precise etiology remains obscure. Aim: To demonstrate the clinical and epidemiological profile of patients with PD as well as to evaluate the main predisposing risk factors related to the disease.

Método

A case-control study was conducted with 156 consecutive PD patients and 254 age-matched controls. Men were interviewed regarding demographic and lifestyle characteristics, co-morbidities and current medication use. International Index of Erectile Function was used to assess the presence and severity of erectile dysfunction. Anthropometric and laboratory evaluations were performed. Potential risk factors for PD were analyzed using bivariate and multivariate models (P <0.05). The effect of PD was studied on the association between ED and age, both by bivariate and multivariate models (P <0.05).

Resultados

White skin color, no married status, abusive consumption of alcoholic beverages and clinical conditions such as hypertension, rheumatologic diseases and Dupuytren´s disease were more commonly associated with PD (P<0.05). Captopril, thiazide diuretics and acetylsalicylic acid were more frequently among PD individuals (P<0.05). LDL-cholesterol levels were lower in PD cases (P=0.04). Association between ED and its severity with PD was observed in the study population and in older men (>60 years of age). Erectile function in younger PD men (<60 years of age) presented higher IIEF scores. Similarly, PD men do not demonstrate an independent association between age and ed-IIEF that was observed in the in control group and in all study population. A clear association between PD and ED was observed. Younger men (<60 years old) with PD presented higher scores of IIEF, which was not observed in the older group (>60 years of age). This study significantly contributes to the epidemiological conclusions of PD, especially related to ed-IIEF and the relationship with age of presentation.    

Conclusão

White skin color, no married status, abusive consumption of alcoholic beverages, hypertension, rheumatologic diseases, Dupuytren´s disease, captopril, thiazide diuretics and ASA were associated with PD. Erectile dysfunction was associated with the presence of PD, except in younger men.